Yes, on the Plus tier and above — and this is usually the deciding factor for anyone in construction. Once enabled, QuickBooks calculates the deduction on the labour element, tracks the materials split separately, produces the monthly CIS return figures, and generates the payment and deduction statements you must give subcontractors within 14 days. It also handles CIS suffered if you are the subcontractor. The setup detail that matters is getting each subcontractor recorded with the correct verified rate at the outset, because the software will apply whatever you tell it and will not know that HMRC said 30%. Enabling CIS also changes how invoices behave, so it wants doing at setup rather than retrofitted mid-year across transactions already posted the other way.